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Article

Insights into diseases of human telomerase from dynamical modeling.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2013

Flores Samuel Coulbourn, Zemora Georgeta, Waldsich Christina

Abstract excerpt

Mutations in the telomerase complex disrupt either nucleic acid binding or catalysis, and are the cause of numerous human diseases. Despite its importance, the structure of the human telomerase complex has not been observed crystallographically, nor are its dynamics understood in detail. Fragments of this complex from Tetrahymena thermophila and Tribolium castaneum have been crystallized. Biochemical probes...

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PMID: 23424125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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