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Article

A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.

Nucleic acids research - 1 Apr 2010

Xie Mingyi, Podlevsky Joshua D, Qi Xiaodong, Bley Christopher J, Chen Julian J-L

Abstract excerpt

Telomerase is a specialized reverse transcriptase that adds telomeric DNA repeats onto chromosome termini. Here, we characterize a new telomerase-specific motif, called motif 3, in the catalytic domain of telomerase reverse transcriptase, that is crucial for telomerase function and evolutionally conserved between vertebrates and ciliates. Comprehensive mutagenesis of motif 3 identified mutations that remarkably...

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Identifiers

PMID: 20044353
DOI: 10.1093/nar/gkp1198
PMCID: PMC2847249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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