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Article

Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.

Nature structural & molecular biology - 1 Mar 2006

Jacobs Steven A, Podell Elaine R, Cech Thomas R

Abstract excerpt

Telomerase, a ribonucleoprotein enzyme, adds telomeric DNA repeats to the ends of linear chromosomes. Here we report the first high-resolution structure of any portion of the telomerase reverse transcriptase, the telomerase essential N-terminal (TEN) domain from Tetrahymena thermophila. The structure, which seems to represent a novel protein fold, shows phylogenetically conserved amino acid residues in a groove...

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Identifiers

PMID: 16462747
DOI: 10.1038/nsmb1054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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