Article
Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.
Molecular and cellular biology - 1 Jan 1996
Gilley D, Blackburn E H
Abstract excerpt
The ribonucleoprotein enzyme telomerase is a specialized reverse transcriptase that synthesizes telomeric DNA by copying a template sequence within the telomerase RNA. Here we analyze the actions of telomerase from Tetrahymena thermophila assembled in vivo with mutated or wild-type telomerase RNA to define further the roles of particular telomerase RNA residues involved in essential enzymatic functions:...
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