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Article

Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function.

Molecular cell - 4 Mar 2005

Theimer Carla A, Blois Craig A, Feigon Juli

Abstract excerpt

Human telomerase contains a 451 nt RNA (hTR) and several proteins, including a specialized reverse transcriptase (hTERT). The 5' half of hTR comprises the pseudoknot (core) domain, which includes the RNA template for telomere synthesis and a highly conserved pseudoknot that is required for telomerase activity. The solution structure of this essential pseudoknot, presented here, reveals an extended triple helix...

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Identifiers

PMID: 15749017
DOI: 10.1016/j.molcel.2005.01.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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