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Article

Zipper head mechanism of telomere synthesis by human telomerase

15 Nov 2021

Abstract excerpt

Telomerase, a multi-subunit ribonucleoprotein complex, is a unique reverse transcriptase that catalyzes the processive addition of a repeat sequence to extend the telomere end using a short fragment of its own RNA component as the template. Despite recent structural characterizations of human and Tetrahymena telomerase, it is still a mystery how telomerase repeatedly uses its RNA template to synthesize telomeric...

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Share to Chromosomal and Genetic Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34782750
DOI: 10.1038/s41422-021-00586-7

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