Article
In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei.
Nucleic acids research - 2 Dec 2021
Dey Abhishek, Monroy-Eklund Anais, Klotz Kaitlin, Saha Arpita, Davis Justin, Li Bibo, Laederach Alain, Chakrabarti Kausik
Abstract excerpt
Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, TR, as its core components. The 5'-half of TR forms a highly conserved catalytic core comprising of the template region and adjacent domains necessary for telomere synthesis....
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