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Article

Parkin, an E3 ubiquitin ligase, enhances airway mitochondrial DNA release and inflammation

4 Jun 2020

Abstract excerpt

Introduction Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent evidence suggests the involvement of Parkin in promoting inflammation. In the present study, we determined if Parkin regulates airway mitochondrial DNA (mtDNA) release and inflammatory responses to type 2 cytokine interleukin (IL)-13 and...

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Identifiers

PMID: 32499407
DOI: 10.1136/thoraxjnl-2019-214158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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