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Article

Mitochondrial reprogramming of neutrophil extracellular traps in chronic obstructive pulmonary disease and asthma: toward a phenotype-driven therapeutic framework.

Frontiers in immunology - 1 Jan 2026

Xu Pei, Xia Fen

Abstract excerpt

Chronic obstructive pulmonary disease (COPD), severe asthma, and asthma-COPD overlap (ACO) represent a major global burden of chronic airway inflammation, often remaining inadequately controlled by current corticosteroid and biologic therapies. Neutrophil extracellular traps (NETs) have emerged as a shared effector mechanism in these phenotypes, with neutrophil mitochondria acting as the upstream switch for...

Read the complete abstract on PubMed

Topics

Humans
Extracellular Traps
Mitochondria
Asthma
Pulmonary Disease, Chronic Obstructive
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Neutrophils

Reactive Oxygen Species

DNA, Mitochondrial

Source

Open in PubMed Open full text

Identifiers

PMID: 42694611
DOI: 10.3389/fimmu.2026.1920684
PMCID: PMC13539345

Genes

GPX4
PGC
PINK1
SLC7A11
TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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