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Article

LRRK2 G2019S enhances immune response pathways and aggravates asthma in mouse models.

Biochemical and biophysical research communications - 19 Nov 2024

Yang Kai, Zhou Yaolong, Cui Jie, Tang Weifeng, Chen Yujun, Chen Xiqun

Abstract excerpt

Asthma is a complex inflammatory airway disease that arises from the interplay between genetic predisposition and environmental influences. Leucine-rich repeat kinase 2 (LRRK2), a gene commonly associated with Parkinson's disease, has recently gained attention for its role in immune regulation and inflammation beyond the brain. However, its involvement in asthma has not yet been reported. In this study, we used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39217812
DOI: 10.1016/j.bbrc.2024.150593

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