Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma

11 Jan 2024

Abstract excerpt

DEK protein is highly expressed in asthma. However, the mechanism of DEK on mitophagy in asthma has not been fully understood. This study aims to investigate the role and mechanism of DEK in asthmatic airway inflammation and in regulating PINK1-Parkin-mediated mitophagy, NLRP3 inflammasome activation, and apoptosis. PINK1-Parkin mitophagy, NLRP3 inflammasome, and apoptosis were examined after gene silencing or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Nuclear Structure and Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38274803
DOI: 10.3389/fimmu.2023.1289774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthmaPMID 38274803Read ↗

Parkin, an E3 ubiquitin ligase, enhances airway mitochondrial DNA release and inflammationSemantic proximity Read ↗

MiT/TFE (TFEB/TFE3) Pathways in Pulmonary Diseases: Current Evidence and Emerging MechanismsSemantic proximity Read ↗

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesisSemantic proximity Read ↗

LRRK2 G2019S enhances immune response pathways and aggravates asthma in mouse models.Semantic proximity Read ↗

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and NecroptosisSemantic proximity Read ↗

CSN5 plays a role in asthma via its interaction with PD-L1Semantic proximity Read ↗

NLRX1 deficiency exacerbates skin inflammation in atopic dermatitis by disrupting mitophagySemantic proximity Read ↗

Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium.Semantic proximity Read ↗

TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytesSemantic proximity Read ↗

MicroRNA 27b-3p Modulates SYK in Pediatric Asthma Induced by Dust MitesSemantic proximity Read ↗

MBD2 mediates Th17 cell differentiation by regulating MINK1 in Th17-dominant asthmaSemantic proximity Read ↗

Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.