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Article

PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses

6 Jun 2019

Abstract excerpt

We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells (AECII) reducing mitophagy and increasing the susceptibility to lung fibrosis. Although increased circulating mitochondrial DNA (mtDNA) has been reported in chronic lung diseases, the contribution of mitophagy in the modulation of mitochondrial DAMP release...

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PMID: 31170232
DOI: 10.1371/journal.pone.0218003

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