Back to search

Article

MEX3B is a positive pan-inflammasome regulator

2026-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Inflammasomes lead to activation of inflammatory caspases, which induce pyroptosis and an inflammatory immune response to control microbial infections. Inflammasomes are tightly regulated to avoid lethal sepsis and chronic autoimmune conditions. However, posttranslational regulation of inflammatory caspases remains poorly defined. We constructed 375 individual ubiquitin ligase knockout lines by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5c4d6861-d26f-560f-aef1-2208f4ecb901
DOI
10.64898/2026.03.30.714824
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
MEX3B is a positive pan-inflammasome regulatorDOI 10.64898/2026.03.30.714824
Regulation of inflammasome activation.Semantic proximity
NLRP3 Inflammasome: Mechanism of Action, Role, and Therapeutics in Liver DiseasesSemantic proximity
Inflammasome Complexes: Emerging Mechanisms and Effector FunctionsSemantic proximity
Inflammasomes: mechanism of action, role in disease, and therapeuticsSemantic proximity
ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.Semantic proximity
TRIMs: Generalists Regulating the NLRP3 Inflammasome Signaling PathwaySemantic proximity
Posttranslational modifications of NLRP3 and their regulatory roles in inflammasome activationSemantic proximity
Negative regulation of NLRP3 inflammasome signalingSemantic proximity
Differential role of the NLRP 3 inflammasome in infection and tumorigenesisSemantic proximity
Inflammasome biology, molecular pathology and therapeutic implicationsSemantic proximity
Inflammasomes: mechanism of assembly, regulation and signallingSemantic proximity
ZBTB7B couples interferon response to mitophagy impairment and inflammasome activation in septic ARDSSemantic proximity
Select a neighboring publication to make it the new centre.