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Article

TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes

15 Mar 2022

Abstract excerpt

BACKGROUND: Thymic stromal lymphopoietin (TSLP) is a Th2-like cytokine involved in asthma pathogenesis. Excessive reactive oxygen species (ROS) production can lead to airway inflammation, hyperresponsiveness and remodeling. Mitophagy, followed by ROS production, is the selective degradation of mitochondria by autophagy and often occurs in defective mitochondria. In the present study, we aimed to examine the...

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PMID: 35292112
DOI: 10.1186/s13578-022-00767-w

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