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Monogenic and Polygenic Models of Coronary Artery Disease.

Current cardiology reports - 1 Jul 2021

Muse Evan D, Chen Shang-Fu, Torkamani Ali

Abstract excerpt

PURPOSE OF THE REVIEW: Coronary artery disease (CAD) is a common disease globally attributable to the interplay of complex genetic and lifestyle factors. Here, we review how genomic sequencing advances have broadened the fundamental understanding of the monogenic and polygenic contributions to CAD and how these insights can be utilized, in part by creating polygenic risk estimates, for improved disease risk...

Topics

Coronary Artery Disease
Genetic Predisposition to Disease
Humans
Multifactorial Inheritance
Prospective Studies
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34196841
DOI: 10.1007/s11886-021-01540-0
PMCID: PMC8317496

Genes

CAD
FH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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