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Article

Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity.

GigaScience - 1 Jun 2020

Chu Benjamin B, Keys Kevin L, German Christopher A, Zhou Hua, Zhou Jin J, Sobel Eric M, Sinsheimer Janet S, Lange Kenneth

Abstract excerpt

BACKGROUND: Consecutive testing of single nucleotide polymorphisms (SNPs) is usually employed to identify genetic variants associated with complex traits. Ideally one should model all covariates in unison, but most existing analysis methods for genome-wide association studies (GWAS) perform only univariate regression. RESULTS: We extend and efficiently implement iterative hard thresholding (IHT) for multiple...

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Identifiers

PMID: 32491161
DOI: 10.1093/gigascience/giaa044
PMCID: PMC7268817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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