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Article

Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso.

BMC bioinformatics - 18 Jan 2010

Yang Can, Wan Xiang, Yang Qiang, Xue Hong, Yu Weichuan

Abstract excerpt

BACKGROUND: Single nucleotide polymorphism (SNP) based association studies aim at identifying SNPs associated with phenotypes, for example, complex diseases. The associated SNPs may influence the disease risk individually (main effects) or behave jointly (epistatic interactions). For the analysis of high throughput data, the main difficulty is that the number of SNPs far exceeds the number of samples. This...

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PMID: 20122189
DOI: 10.1186/1471-2105-11-S1-S18
PMCID: PMC3203332

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AGL

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