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Article

Multivariate genome-wide association analysis by iterative hard thresholding.

Bioinformatics (Oxford, England) - 3 Apr 2023

Chu Benjamin B, Ko Seyoon, Zhou Jin J, Jensen Aubrey, Zhou Hua, Sinsheimer Janet S, Lange Kenneth

Abstract excerpt

MOTIVATION: In a genome-wide association study, analyzing multiple correlated traits simultaneously is potentially superior to analyzing the traits one by one. Standard methods for multivariate genome-wide association study operate marker-by-marker and are computationally intensive. RESULTS: We present a sparsity constrained regression algorithm for multivariate genome-wide association study based on iterative...

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PMID: 37067496
DOI: 10.1093/bioinformatics/btad193
PMCID: PMC10133532

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