Article

Iterative Hard Thresholding in GWAS: Generalized Linear Models, Prior Weights, and Double Sparsity

2019-07-11

Abstract excerpt

1 <h4>Background</h4> Consecutive testing of single nucleotide polymorphisms (SNPs) is usually employed to identify genetic variants associated with complex traits. Ideally one should model all covariates in unison, but most existing analysis methods for genome-wide association studies (GWAS) perform only univariate regression. <h4>Results</h4> We extend and efficiently implement iterative hard thresholding (IHT...

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Literature Corpus work: 571e11f7-6836-577d-a909-921e5ea5efd7
DOI: 10.1101/697755

Open publication

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