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Article

Iterative hard thresholding for model selection in genome-wide association studies.

Genetic epidemiology - 1 Dec 2017

Keys Kevin L, Chen Gary K, Lange Kenneth

Abstract excerpt

A genome-wide association study (GWAS) correlates marker and trait variation in a study sample. Each subject is genotyped at a multitude of SNPs (single nucleotide polymorphisms) spanning the genome. Here, we assume that subjects are randomly collected unrelateds and that trait values are normally distributed or can be transformed to normality. Over the past decade, geneticists have been remarkably successful in...

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Identifiers

PMID: 28875524
DOI: 10.1002/gepi.22068
PMCID: PMC5696071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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