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Article

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

3 Mar 2020

Abstract excerpt

Despite a critical role for MYC as an effector of oncogenic RAS, strategies to target MYC activity in RAS-driven cancers are lacking. In genetically engineered mouse models of lung and pancreatic cancer, oncogenic KRAS is insufficient to drive tumorigenesis, while addition of modest MYC overexpression drives robust tumor formation, suggesting that mechanisms beyond the RAS pathway play key roles in MYC regulation...

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PMID: 32434218
DOI: 10.1084/jem.20191805

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