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Article

Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression.

Cancer research - 1 Mar 2018

Dauer Patricia, Zhao Xianda, Gupta Vineet K, Sharma Nikita, Kesh Kousik, Gnamlin Prisca, Dudeja Vikas, Vickers Selwyn M, Banerjee Sulagna, Saluja Ashok

Abstract excerpt

Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) that stimulate oncogenic signaling in TEC. In this study, we evaluated the cross-talk between CAF and TEC isolated from tumors generated in a mouse model of KRAS/mut p53-induced pancreatic cancer (KPC mice). Transcriptomic profiling conducted after treatment with the anticancer...

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Identifiers

PMID: 29259015
DOI: 10.1158/0008-5472.CAN-17-2320
PMCID: PMC5935584

Genes

TEC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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