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Article

KRAS Oncogenic Signaling Extends beyond Cancer Cells to Orchestrate the Microenvironment.

Cancer research - 1 Jan 2018

Dias Carvalho Patrícia, Guimarães Carlos F, Cardoso Ana P, Mendonça Susana, Costa Ângela M, Oliveira Maria J, Velho Sérgia

Abstract excerpt

KRAS is one of the most frequently mutated oncogenes in cancer, being a potent initiator of tumorigenesis, a strong inductor of malignancy, and a predictive biomarker of response to therapy. Despite the large investment to understand the effects of KRAS activation in cancer cells, pharmacologic targeting of KRAS or its downstream effectors has not yet been successful at the clinical level. Recent studies are now...

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Source

Identifiers

PMID: 29263151
DOI: 10.1158/0008-5472.CAN-17-2084

Genes

KRAS

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