Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics.

doi:10.1038/s41388-022-02288-9

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Article

Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics.

Oncogene - 1 May 2022

Iida Tadashi, Mizutani Yasuyuki, Esaki Nobutoshi, Ponik Suzanne M, Burkel Brian M, Weng Liang, Kuwata Keiko, Masamune Atsushi, Ishihara Seiichiro, Haga Hisashi, Kataoka Kunio, Mii Shinji, Shiraki Yukihiro, Ishikawa Takuya, Ohno Eizaburo, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro, Takahashi Masahide, Enomoto Atsushi

Abstract excerpt

Previous therapeutic attempts to deplete cancer-associated fibroblasts (CAFs) or inhibit their proliferation in pancreatic ductal adenocarcinoma (PDAC) were not successful in mice or patients. Thus, CAFs may be tumor suppressive or heterogeneous, with distinct cancer-restraining and -promoting CAFs (rCAFs and pCAFs, respectively). Here, we showed that induced expression of the...

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PMID: 35414659
DOI: 10.1038/s41388-022-02288-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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