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Article

HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation

14 Mar 2023

Abstract excerpt

High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors where they portend adverse outcomes, although how they function in cancer remains unclear. Pancreatic ductal adenocarcinomas (PDACs) are highly lethal tumors characterized by dense desmoplastic stroma composed predominantly of cancer-associated fibroblasts and fibrotic tissue. Here, we uncover an epigenetic program whereby HMGA1...

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PMID: 36919699
DOI: 10.1172/jci151601

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