Article

Preventing cancer by long-term partial Myc suppression

2020-12-31

Abstract excerpt

Myc +/− haploinsufficient mice and mice with deleted Myc enhancers express reduced levels of the pleiotropic transcription factor Myc. Such mice are viable, with relatively mild pathologies, but show delay in onset of certain cancers. However, many phenotypes arising from germline gene perturbation are indirect consequences of adaptive developmental compensation and so do not translate to equivalent phenotypes w...

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Identifiers and source

Literature Corpus work: ed9d9930-da7b-5181-aeea-897947e76ad2
DOI: 10.1101/2020.12.30.422650

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