Article
Modelling Myc inhibition as a cancer therapy.
Nature - 2 Oct 2008
Soucek Laura, Whitfield Jonathan, Martins Carla P, Finch Andrew J, Murphy Daniel J, Sodir Nicole M, Karnezis Anthony N, Swigart Lamorna Brown, Nasi Sergio, Evan Gerard I
Abstract excerpt
Myc is a pleiotropic basic helix-loop-helix leucine zipper transcription factor that coordinates expression of the diverse intracellular and extracellular programs that together are necessary for growth and expansion of somatic cells. In principle, this makes inhibition of Myc an attractive pharmacological approach for treating diverse types of cancer. However, enthusiasm has been muted by lack of direct evidence...
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