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Article

A comprehensive, high-resolution map of a gene's fitness landscape.

Molecular biology and evolution - 1 Jun 2014

Firnberg Elad, Labonte Jason W, Gray Jeffrey J, Ostermeier Marc

Abstract excerpt

Mutations are central to evolution, providing the genetic variation upon which selection acts. A mutation's effect on the suitability of a gene to perform a particular function (gene fitness) can be positive, negative, or neutral. Knowledge of the distribution of fitness effects (DFE) of mutations is fundamental for understanding evolutionary dynamics, molecular-level genetic variation, complex genetic disease,...

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Identifiers

PMID: 24567513
DOI: 10.1093/molbev/msu081
PMCID: PMC4032126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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