Article
The molecular diversity of adaptive convergence.
Science (New York, N.Y.) - 27 Jan 2012
Tenaillon Olivier, Rodríguez-Verdugo Alejandra, Gaut Rebecca L, McDonald Pamela, Bennett Albert F, Long Anthony D, Gaut Brandon S
Abstract excerpt
To estimate the number and diversity of beneficial mutations, we experimentally evolved 115 populations of Escherichia coli to 42.2°C for 2000 generations and sequenced one genome from each population. We identified 1331 total mutations, affecting more than 600 different sites. Few mutations were shared among replicates, but a strong pattern of convergence emerged at the level of genes, operons, and functional...
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