Robust genetic codes enhance protein evolvability.

Abstract excerpt

The standard genetic code defines the rules of translation for nearly every life form on Earth. It also determines the amino acid changes accessible via single-nucleotide mutations, thus influencing protein evolvability-the ability of mutation to bring forth adaptive variation in protein function. One of the most striking features of the standard genetic code is its robustness to mutation, yet it remains an open...

Topics

• Genetic Code
• Evolution, Molecular
• Proteins
• Mutation
• Codon
• Models, Genetic
• Synthetic Biology
• Protein Biosynthesis
• Protein Engineering