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Article

Mapping the in vivo fitness landscape of a tethered ribosome.

Science advances - 28 Apr 2023

Radford Felix, Rinehart Jesse, Isaacs Farren J

Abstract excerpt

Fitness landscapes are models of the sequence space of a genetic element that map how each sequence corresponds to its activity and can be used to guide laboratory evolution. The ribosome is a macromolecular machine that is essential for protein synthesis in all organisms. Because of the prevalence of dominant lethal mutations, a comprehensive fitness landscape of the ribosomal peptidyl transfer center (PTC) has...

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Identifiers

PMID: 37115918
DOI: 10.1126/sciadv.ade8934
PMCID: PMC10146877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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