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Article

Fitness and Functional Landscapes of the E. coli RNase III Gene rnc.

Molecular biology and evolution - 4 Mar 2023

Weeks Ryan, Ostermeier Marc

Abstract excerpt

How protein properties such as protein activity and protein essentiality affect the distribution of fitness effects (DFE) of mutations are important questions in protein evolution. Deep mutational scanning studies typically measure the effects of a comprehensive set of mutations on either protein activity or fitness. Our understanding of the underpinnings of the DFE would be enhanced by a comprehensive study of...

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Identifiers

PMID: 36848192
DOI: 10.1093/molbev/msad047
PMCID: PMC10037077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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