Article
Multi-environment fitness landscapes of a tRNA gene.
Nature ecology & evolution - 1 Jun 2018
Li Chuan, Zhang Jianzhi
Abstract excerpt
A fitness landscape (FL) describes the genotype-fitness relationship in a given environment. To explain and predict evolution, it is imperative to measure the FL in multiple environments because the natural environment changes frequently. Using a high-throughput method that combines precise gene replacement with next-generation sequencing, we determine the in vivo FL of a yeast tRNA gene comprising over 23,000...
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