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Inference and Visualization of Complex Genotype-Phenotype Maps.

Molecular biology and evolution - 2 Feb 2026

Martí-Gómez Carlos, Zhou Juannan, Chen Wei-Chia, Stoltzfus Arlin, Kinney Justin B, McCandlish David M

Abstract excerpt

Understanding how biological sequences give rise to observable traits, that is, how genotype maps to phenotype, is a central goal in biology. Yet, our knowledge of genotype-phenotype maps in natural systems remains limited by the high dimensionality of sequence space and the context-dependent effects of mutations. The emergence of Multiplex assays of variant effect (MAVEs) and the availability of ever growing...

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Identifiers

PMID: 41631708
DOI: 10.1093/molbev/msag023
PMCID: PMC12911936

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