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Article

Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.

Frontiers in immunology - 1 Jan 2020

Olmedillas Del Moral Maria, Fröhlich Nicole, Figarella Katherine, Mojtahedi Nima, Garaschuk Olga

Abstract excerpt

Throughout the lifespan, microglia, the primary innate immune cells of the brain, fulfill a plethora of homeostatic as well as active immune defense functions, and their aging-induced dysfunctionality is now considered as a key trigger of aging-related brain disorders. Recent evidence suggests that both organism's sex and age critically impact the functional state of microglia but in vivo determinants of such...

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Identifiers

PMID: 32411143
DOI: 10.3389/fimmu.2020.00750
PMCID: PMC7198715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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