Article

Chemically induced senescence prompts functional changes in human microglia-like cells

2024-02-28

Abstract excerpt

In response to various stressors, cells can enter a state called cellular senescence which is characterized by irreversible cell cycle arrest and a senescence-associated secretory phenotype (SASP). The progressive accumulation of senescent glial cells in the central nervous system (CNS) with aging suggests a potential role for senescence as driver of aging and inflammation in the brain. As the main immune cell pop...

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Literature Corpus work: 4372427e-5039-5f22-a505-62e7103ac9db
DOI: 10.1101/2024.02.27.582168

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