Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop 'G4 Kissing' interaction.

doi:10.1093/nar/gkaa357

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Article

Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop 'G4 Kissing' interaction.

Nucleic acids research - 19 Jun 2020

Williams Jonathan D, Houserova Dominika, Johnson Bradley R, Dyniewski Brad, Berroyer Alexandra, French Hannah, Barchie Addison A, Bilbrey Dakota D, Demeis Jeffrey D, Ghee Kanesha R, Hughes Alexandra G, Kreitz Naden W, McInnis Cameron H, Pudner Susanna C, Reeves Monica N, Stahly Ashlyn N, Turcu Ana, Watters Brianna C, Daly Grant T, Langley Raymond J, Gillespie Mark N, Prakash Aishwarya, Larson Erik D, Kasukurthi Mohan V, Huang Jingshan, Jinks-Robertson Sue, Borchert Glen M

Abstract excerpt

Mammalian antibody switch regions (∼1500 bp) are composed of a series of closely neighboring G4-capable sequences. Whereas numerous structural and genome-wide analyses of roles for minimal G4s in transcriptional regulation have been reported, Long G4-capable regions (LG4s)-like those at antibody switch regions-remain virtually unexplored. Using a novel computational approach we have identified 301 LG4s in the...

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PMID: 32383760
DOI: 10.1093/nar/gkaa357
PMCID: PMC7293029

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Source receipt: pubmed, retrieved 7 Sept 2026.

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