Article

BisMapR: a strand-specific, nuclease-based method for genome-wide R-loop detection

2021-01-23

Abstract excerpt

R-loops are three stranded nucleic acid structures with essential roles in many nuclear processes. However, their unchecked accumulation as seen in some neurodevelopmental diseases and cancers and is associated with compromised genome stability. Genome-wide profiling of R-loops in normal cells and their comparison in disease states can help identify precise locations of pathogenic R-loops and advance efforts to at...

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Literature Corpus work: f8a88f3e-bb2f-5892-8a84-17bcc6e4eabd
DOI: 10.1101/2021.01.22.427764

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