Article
G4 motifs in human genes.
Annals of the New York Academy of Sciences - 1 Sept 2012
Maizels Nancy
Abstract excerpt
The G4 motif, G(≥3) N(x) G(≥3) N(x) G(≥3) N(x) G(≥3) , is enriched in some genomic regions and depleted in others. This motif confers the ability to form an unusual four-stranded DNA structure, G4 DNA. G4 DNA is associated with genomic instability, which may explain depletion of G4 motifs from some genes and genomic regions. Conversely, G4 motifs are enriched downstream of transcription start sites, where they...
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