Article

G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironments

2023-01-19

Abstract excerpt

Breast cancer is characterised by genetic and epigenetic alterations, such as G-quadruplex (G4) DNA secondary structures. Here, we uncover differentially enriched G4 structure-forming regions (∆G4Rs) and interlinked transcriptomes in the tumour microenvironment (TME) of breast cancer PDX models in vivo . We show that well-defined breast cancer cell models non-autonomously instruct ∆G4Rs and transcriptomes in the...

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Literature Corpus work: a5e603fe-0fdd-5719-adab-9d2d37469d18
DOI: 10.1101/2023.01.16.524243

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