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Article

TEX15 associates with MILI and silences transposable elements in male germ cells.

Genes & development - 1 Jun 2020

Yang Fang, Lan Yemin, Pandey Radha Raman, Homolka David, Berger Shelley L, Pillai Ramesh S, Bartolomei Marisa S, Wang P Jeremy

Abstract excerpt

DNA methylation is a major silencing mechanism of transposable elements (TEs). Here we report that TEX15, a testis-specific protein, is required for TE silencing. TEX15 is expressed in embryonic germ cells and functions during genome-wide epigenetic reprogramming. The Tex15 mutant exhibits DNA hypomethylation in TEs at a level similar to Mili and Dnmt3c but not Miwi2 mutants. TEX15 is associated with MILI in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32381626
DOI: 10.1101/gad.335489.119
PMCID: PMC7263141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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