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Article

Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.

Experimental gerontology - 1 Nov 2010

Zhang Hongjun, Li Yishi, Yang Junsheng, Tominaga Kaoru, Pereira-Smith Olivia M, Tower John

Abstract excerpt

The mammalian MRG15 gene encodes a chromodomain protein predicted to bind to chromatin via methylated histone tails. Human MORF4 encodes a related but truncated protein that is capable of promoting cellular senescence in a subset of human tumor cell lines. Drosophila contains a single homolog of human MRG15, called DmMRG15. Null mutation of MRG15 is embryonic-lethal in mice and Drosophila, making the study of...

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Identifiers

PMID: 20600782
DOI: 10.1016/j.exger.2010.06.002
PMCID: PMC2952352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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