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SUMOylation of Bonus, the <i>Drosophila</i> homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes

2023-04-15

Abstract excerpt

The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Drosophila only encodes one member of the family, Bonus. Bonus has been implicated in embryonic development and organogenesis and shown to regulate several signaling pathways, howe...

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Literature Corpus work
fa1627c5-fb98-5735-adb1-a41078027484
DOI
10.1101/2023.04.14.536936
Open publication

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SUMOylation of Bonus, the <i>Drosophila</i> homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genesDOI 10.1101/2023.04.14.536936
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