Article

Mod(mdg4) variants repress telomeric retrotransposon <i>HeT-A</i> by blocking subtelomeric enhancers

2022-01-17

Abstract excerpt

<h4>Summary</h4> Telomeres in Drosophila are composed of sequential non-LTR retrotransposons: HeT-A, TART , and TAHRE . Although they are repressed by the piRNA pathway in the germline, how these retrotransposons are regulated in somatic cells is poorly understood. Here, we show that specific splice variants of Mod(mdg4) repress HeT-A by blocking subtelomeric enhancers in ovarian somatic cells. We found that...

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Literature Corpus work: f7ccb8fc-684e-57f4-966d-320cea42f187
DOI: 10.1101/2022.01.16.476534

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