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Article

DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary.

Genes & development - 1 Aug 2013

Ohtani Hitoshi, Iwasaki Yuka W, Shibuya Aoi, Siomi Haruhiko, Siomi Mikiko C, Saito Kuniaki

Abstract excerpt

The Piwi-piRNA (PIWI-interacting RNA) complex (Piwi-piRISC) in Drosophila ovarian somatic cells represses transposons transcriptionally to maintain genome integrity; however, the underlying mechanisms remain obscure. Here, we reveal that DmGTSF1, a Drosophila homolog of gametocyte-specific factor 1 (GTSF1) (which is required for transposon silencing in mouse testes), is necessary for Piwi-piRISC to repress target...

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Source

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Identifiers

PMID: 23913921
DOI: 10.1101/gad.221515.113
PMCID: PMC3744724

Genes

GTSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary.PMID 23913921Read ↗

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