Article

PIWI proximity proteome reveals Set1-mediated piRNA biogenesis for transposon silencing in telomere

2026-03-30

Abstract excerpt

Silencing complexes formed by PIWI-clade Argonaute (Ago) proteins and PIWI-interacting RNAs (piRNAs) are essential guardians of genome integrity, controlling the deleterious activities of transposable elements (TEs) in animal germline. However, our understanding of PIWI-piRNA-directed TE silencing remains incomplete. Here, we systemically characterize the proximity proteome of PIWI members, Piwi, Aubergine (Aub),...

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Literature Corpus work: 68d0a0e6-ee9a-566c-8228-a8cbce594392
DOI: 10.64898/2026.03.30.715253

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