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Article

Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila.

Genes & development - 1 Apr 2016

Hur Junho K, Luo Yicheng, Moon Sungjin, Ninova Maria, Marinov Georgi K, Chung Yun D, Aravin Alexei A

Abstract excerpt

The conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by RNA polymerase II in a splicing-dependent fashion; however, how TREX functions is poorly understood. Here we show that Thoc5 and other TREX components are essential for the biogenesis of piRNA, a distinct class of small noncoding RNAs that...

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Identifiers

PMID: 27036967
DOI: 10.1101/gad.276030.115
PMCID: PMC4826399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila.PMID 27036967Read ↗

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