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Article

Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.

The Journal of cell biology - 25 Feb 2008

Yang Fang, Eckardt Sigrid, Leu N Adrian, McLaughlin K John, Wang Peijing Jeremy

Abstract excerpt

During meiosis, homologous chromosomes undergo synapsis and recombination. We identify TEX15 as a novel protein that is required for chromosomal synapsis and meiotic recombination. Loss of TEX15 function in mice causes early meiotic arrest in males but not in females. Specifically, TEX15-deficient spermatocytes exhibit a failure in chromosomal synapsis. In mutant spermatocytes, DNA double-strand breaks (DSBs) are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18283110
DOI: 10.1083/jcb.200709057
PMCID: PMC2265566

Genes

TEX15
DMC1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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