Article
Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
PLoS genetics - 1 Dec 2015
Isbel Luke, Srivastava Rahul, Oey Harald, Spurling Alex, Daxinger Lucia, Puthalakath Hamsa, Whitelaw Emma
Abstract excerpt
Transposable elements (TEs) have been active in the mammalian genome for millions of years and the silencing of these elements in the germline is important for the survival of the host. Mice carrying reporter transgenes can be used to model transcriptional silencing. A mutagenesis screen for modifiers of epigenetic gene silencing produced a line with a mutation in Trim33; the mutants displayed increased...
Topics
- Animals
- Gene Silencing
- Genome
- Histones
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Protein Binding
- Proto-Oncogene Proteins c-myb
- Retroelements
- Retroviridae
- Terminal Repeat Sequences
- Testis