Article

Loss of region-specific glial homeostatic signature in prion diseases

2019-10-30

Abstract excerpt

<h4>Background</h4> Chronic neuroinflammation is recognized as a major neuropathological hallmark in a broad spectrum of neurodegenerative diseases including Alzheimer’s, Parkinson’s, Frontal Temporal Dementia, Amyotrophic Lateral Sclerosis, and prion diseases. Both microglia and astrocytes exhibit region-specific homeostatic transcriptional identities, which under chronic neurodegeneration, transform into reacti...

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Literature Corpus work: 3cc0be4b-0f13-55d0-aad6-fd3be2af12ea
DOI: 10.1101/823732

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